Efficacy Testing

Cosmetic Claim Support

Our animal-free tests are used by leading cosmetic companies and ingredient suppliers to demonstrate efficacy and provide valuable claim support data.  Unlike our safety testing work, efficacy studies tend to be customised, since each project has bespoke requirements depending on the type of product and the desired claims – so we recommend contacting us at an early stage of product development, to discuss how we can support your project.  In many cases, the tests can provide key pieces of information prior to finalising a formulation for testing on human volunteer panels, as well as producing innovative claim support data that will appeal to both formulators and consumers.

Some of our most commonly used efficacy tests for cosmetic ingredients and formulations include:

An important note of caution:

Currently, in vitro tests do not usually act as “stand-alone” evidence for cosmetic claim substantiation.  In the absence of a definitive regulatory framework for the application of in vitro data in the field of claim support, each ingredient or formulation must be carefully considered on a case-by-case basis.  The results must always be applied in compliance with local regulations and advertising standards in the relevant territories of the world where you intend to sell the product.  There is no doubt that these sensitive tests provide valuable, mechanistic information that is often more detailed and conclusive than human trials alone, but, like all test methods, they must be applied in an appropriate context.

 

 

ANTI-OXIDANT ACTIVITY

  • OxiSelectTM method
  • Measures anti-oxidant activity relative to controls
  • Human dermal fibroblasts and / or human epidermal keratinocytes
  • Animal product-free test conditions
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MILDNESS TO SKIN

  • ET50 method
  • Reconstructed human skin models
  • Measures cellular damage in the epithelium
  • Classifies in rank order of mildness compared with benchmarks
  • Suitable for ingredients and formulations
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MILDNESS TO EYE

  • ET50 method
  • Reconstructed human eye models
  • Measures cellular damage in the epithelium
  • Classifies in rank order of mildness compared with benchmarks
  • Suitable for ingredients and formulations
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SKIN PIGMENTATION

  • MelanoDerm method
  • Reconstructed human skin model with melanocytes
  • Measures modulation of melanin levels
  • Supports claims for skin lighteners, self-tanning and anti-blemish products
  • Suitable for ingredients and formulations
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COLLAGEN EXPRESSION

  • ELISA method
  • Measures collagen expression relative to controls
  • Human dermal fibroblasts
  • Animal product-free test conditions

MATRIX METALLOPROTEINASE (MMP) EXPRESSION

  • ELISA method
  • Measures MMP expression relative to controls
  • Human dermal fibroblasts
  • Animal product-free test conditions