What is the BCOP test?

The Bovine Cornea Opacity/Permeability test (BCOP) is an alternative ocular irritation assay designed to replace the rabbit eye test. It is commonly utilized to test for eye irritation and corrosive potential of test materials that may be used in or around the eye. The BCOP uses excised bovine corneas, normally discarded as waste in the production of beef and does not utilise live animals for research. 

If you are truly against animal testing, wanting to claim this on pack and to consumers, or are working with a vegan brand or products then can you hand-on-heart be happy using BCOP for your eye irritation studies? 

Ocular Irritection OECD TG 496 – APF score 7  

Ocular Irritection® is a fully defined, biochemical in vitro test that investigates the potential of a substance to cause serious damage, or no irritation to the eye. Eye irritation is a reversible condition caused by changes to the surface of the eye, whereas serious eye damage is not expected to be reversible within 21 days. This method models changes to corneal opacity by observing the effect of a test chemical on a macromolecular reagent matrix. The test can determine whether a substance causes serious eye damage or has no required classification for irritation or eye damage and is an effective first step for a top-down or bottom-up approach to testing as defined in the OECD’s Guidance Document 263: Integrated Approaches to Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. 

Do you have an ingredient or product you need testing? Get in touch today to start your animal-free testing journey.