How Do You Know? A Short History of GLP
In the 1970s, one of the largest toxicology laboratories in the United States was found to have been fabricating safety data on an industrial scale. Industrial Bio-Test Laboratories ran studies underpinning regulatory approvals for pesticides, industrial chemicals and...
Collagen Boosting – The Claim Everyone Wants and How to Substantiate It
Collagen has become a central idea in anti-ageing skincare, and the framing around it has shifted. The industry now talks about “collagen banking”: acting before collagen decline becomes visible rather than correcting it afterwards. In practice that means...
KeratinoSens™ and the Animal-Free Test That Used Animal Serum
In the last artlcle of this series on our core regulatory tests we’re covering KeratinoSens™ (OECD TG442d). The Adverse Outcome Pathway for skin sensitisation, published by the OECD in 2012, broke allergic contact dermatitis into a sequence of Key Events. A chemical...
OECD TG 492B: The Eye Test That Finally Answered the Whole Question
This is the third article in our run through our regulatory safety testing suite, and after skin irritation and skin corrosion, the eye is where the approach behind both ran into difficulty. Skin irritation and skin corrosion both use reconstructed human tissue, MTT...