Eye irritation testing

Whether you are looking for regulatory or non-regulatory compliance, all three of our in vitro eye irritation tests are conducted in our GLP accredited laboratory.

REGULATORY EYE IRRITATION TEST

For those seeking a regulatory test for hazard identification and labelling for compliance with a range of legislation including REACH and the CLP Regulation, we can provide eye irritation test OECD Test Guideline 492 (reconstructed human cornea-like epithelium method.) This will give your ingredient or formulation a binary classification of either Irritant or Non-Irritant. It is approved for chemicals not requiring classification and labelling for eye irritation or serious eye damage, but is NOT intended to differentiate between UN GHS Category 1 (serious eye damage) and UN GHS Category 2 (eye irritation).

MORE ON EYE IRRITATION OECD TG 492

NON-REGULATORY EYE IRRITATION TESTS

For non-regulatory potency assessments of eye irritation potential, our modification known as the “ET50” method, provides a profile of damage to the cornea over time. This results in a more detailed classification as a Severe, Moderate, Mild or Minimal / Non-Irritant. The ET50 value (time taken to reduce the cell viability by 50%) can be used to place a series of ingredients or formulations into rank order of irritation potential, and to compare against industry benchmarks. A special extended protocol is available for mild and ultra-mild test items.

MORE ON EYE IRRITATION ET50

MORE ON SKIN IRRITATION ET50 ULTRA-MILD

 

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