Skin irritation

XCellR8’s GLP-accredited laboratory provides two in vitro skin irritation tests to meet your regulatory and non-regulatory needs.

REGULATORY SKIN IRRITATION TEST

If you’re looking for a regulatory test for hazard identification and labelling for compliance with a range of legislation including REACH and the CLP Regulation, we offer skin irritation test OECD Test Guideline 439 (reconstructed human epidermis method.) This will give your ingredient or formulation a binary classification of either Irritant or Non-Irritant.

MORE ON SKIN IRRITATION OECD TG 439

NON-REGULATORY SKIN IRRITATION TEST

For non-regulatory potency assessments of skin irritation potential, we recommend a modification known as the “ET50” method, which provides a profile of damage to the epidermis over time.

This results in a more detailed classification as a Severe, Moderate, Mild or Minimal / Non-Irritant. The ET50 value (time taken to reduce the cell viability by 50%) can be used to place a series of ingredients or formulations into rank order of irritation potential, and to compare against industry benchmarks.

MORE ON SKIN IRRITATION ET50

 

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