Vaginal irritation testing

XCellR8’s GLP-accredited laboratory provides an in vitro test for human vaginal irritation.

The method uses an in vitro reconstructed model of the human vaginal epithelium for non-regulatory potency assessments of vaginal irritation potential. The method is suitable for ingredients and final formulations, which are applied to the tissue surface for defined exposure times.

The output of the test is an ET50 value (time taken to reduce the viability of the tissue model by 50%). The ET50 value can be used to place a series of items into a rank order of irritation potential and to compare against known benchmarks.

A special extended protocol is also available for mild and ultra-mild test items.

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