In this easily digestible ebook, you will learn:

    • How in vitro DPRA, KeratinoSens™ and h-CLAT tests work

    The pathway for skin sensitisation is notoriously complex. The guide explains how the three tests measure human responses to a chemical at three points in the AOP.

    • What is the current OECD guidance for the three tests

    What is the right testing programme for your organisation and when should you adopt the “two out of three” approach whereby two positive results would lead to classification of a chemical as a skin sensitiser.

    • The latest thinking on how to predict potency

    We explain how SenzaGen’s GARD™skin assay and GARD™potency add-on measure gene expression to help assess potency.

    • The relevance of the tests for mixtures and formulations

    If the tests were validated using a panel of individual reference chemicals, how can companies in the cosmetic, agrochemical, household product and medical device sectors use the tests to ensure the safety of finished products?

    • Case study from global retailer Lush

    Study live results from Lush, revealing how it has tested over 140 finished products for their skin sensitisation potential

“I have been delighted with XCellR8’s service and especially the explanation and mentoring, often about emerging methodology, which has been invaluable.”


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