Safety case study


Use of 3 Animal Product-Free Methods as Part of a Novel Integrated Approach to Skin Sensitisation Testing

An integrated approach to in chemico and in vitro skin sensitisation using three methods; Direct Peptide Reactivity Assay (DPRA), KeratinoSens™ and human Cell Line Activation Test (h-CLAT), has recently been approved by the OECD. Here, we present novel data from 2 representative case studies using animal product-free adaptations of the 2 in vitro skin sensitisation methods alongside data from the in chemico DPRA method. Animal product-free adaptations to h-CLAT and KeratinoSens™ include the use of Human Serum, Human Serum Albumin, custom anti-CD54 and anti-CD86 antibodies produced using phage display, and Trypzean from plant sources to replace the use of animal derived components.

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