SAFETY TESTING
XCELLR8’s lab is Good Laboratory Practice (GLP) accredited by the MHRA (Medicines and Healthcare Products Regulatory Agency) for in vitro safety testing.
Our range of tests, including genotoxicity testing and various forms of cosmetics testing, supports compliance with legislation such as the Cosmetics Regulation 1223/2009, CLP Regulation 1272/2008 and REACH.
<div class="sidebar"><!-- [et_pb_line_break_holder] --><aside><!-- [et_pb_line_break_holder] --><ul><!-- [et_pb_line_break_holder] --><!-- <h4> Sub menu: Testing </h4> --><!-- [et_pb_line_break_holder] --><!-- <ul> --><!-- [et_pb_line_break_holder] --><li class="page_item page-item-56"><a href="https://x-cellr8.com/testing/efficacy-testing/">Efficacy Testing</a></li><!-- [et_pb_line_break_holder] --><li class="page_item page-item-58"><a href="https://x-cellr8.com/testing/in-development/">In Development</a></li><!-- [et_pb_line_break_holder] --><li class="page_item page-item-54 current_page_item"><a href="https://x-cellr8.com/testing/safety-testing/">Safety Testing</a></li><!-- [et_pb_line_break_holder] --><!-- </ul> --><!-- [et_pb_line_break_holder] --></ul><!-- [et_pb_line_break_holder] --></aside><!-- [et_pb_line_break_holder] --></div>
LOOKING FOR A DIFFERENT TEST?
Please contact us to discuss your requirements.
SKIN IRRITATION – for hazard identification
- OECD Test Guideline 439
- Reconstructed human epidermis
- Provides classification as a Skin Irritant (UN GHS Class 2) or Non-Irritant (No Label)
SKIN IRRITATION – for product development (potency assessment)
- Non-regulatory
- Reconstructed human epidermis
- Provides classification as a Severe, Moderate, Mild or Minimal / Non-Irritant
- May be used to classify a series of products or ingredients in rank order of irritation potential
SKIN CORROSION
- OECD Test Guideline 431
- Reconstructed human epidermis
- Provides classification of skin corrosive chemicals according to UN GHS (Categories 1A, 1B-1C)
SKIN SENSITISATION – Direct Peptide Reactivity Assay (DPRA)
- OECD Test Guideline 442c
- Measures binding to skin proteins
- Provides classification as a Sensitiser (High, Moderate or Low reactivity class) or Non-Sensitiser (Minimal reactivity class)
SKIN SENSITISATION – KeratinoSensTM
- OECD Test Guideline 442d
- Measures activation of skin cells (keratinocytes)
- Animal product-free test conditions
- Provides classification as a Sensitiser or Non-Sensitiser
EYE IRRITATION – for hazard identification
- Draft OECD Test Guideline (full regulatory acceptance expected 2015)
- Reconstructed human cornea-like epithelium (EpiOcularTM)
- Eye Irritation Test (EIT) method
- Provides classification as an Eye Irritant (UN GHS Class 2) or Non-Irritant (No Label)
EYE IRRITATION – for product development (potency assessment)
- Non-regulatory
- Reconstructed human cornea-like epithelium (EpiOcularTM)
- ET50 method
- Provides classification as a Severe, Moderate, Mild or Minimal / Non-Irritant
- May be used to classify a series of products or ingredients in rank order of irritation potential
EYE IRRITATION – for product development (mild and ultra-mild products and ingredients)
- Non-regulatory
- Reconstructed human cornea-like epithelium (EpiOcularTM)
- “Sub-Draize” method
- May be used to classify a series of products or ingredients in rank order of irritation potential, and / or compare with market leaders
GENOTOXICITY
- Non-regulatory
- BlueScreenTM method
- Provides classification as a Genotoxin or Non-Genotoxin
- Detects all three major classes of genotoxin (mutagens; aneugens; clastogens)
- Animal product-free test conditions
CYTOTOXICITY
- Non-regulatory
- MTT method (measures metabolic activity) and / or:
- Neutral Red Uptake (NRU) method (measures cell membrane integrity)
- Provides percentage viability over a range of test concentrations and IC50 value
- Human dermal fibroblasts
- Animal product-free test conditions