IN THIS EASILY DIGESTIBLE EBOOK, YOU WILL LEARN:

• How in vitro DPRA, KeratinoSens™ and h-CLAT tests work

The pathway for skin sensitisation is notoriously complex. The guide explains how the three tests measure human responses to a chemical at three points in the AOP.

• What is the current OECD guidance for the three tests

What is the right testing programme for your organisation and when should you adopt the “two out of three” approach whereby two positive results would lead to classification of a chemical as a skin sensitiser.

• The latest thinking on how to predict potency

We explain how SenzaGen’s GARD™skin assay and GARD™potency add-on measure gene expression to help assess potency.

• The relevance of the tests for mixtures and formulations

If the tests were validated using a panel of individual reference chemicals, how can companies in the cosmetic, agrochemical, household product and medical device sectors use the tests to ensure the safety of finished products?

• Case study from global retailer Lush

Study live results from Lush, revealing how it has tested over 140 finished products for their skin sensitisation potential

“This ebook is a great tool for regulatory scientists. The replacement, refinement and reduction of animals used in scientific procedures for the elucidation of human skin sensitisation potential is a great step forward scientifically and ethically, but the relatively new structure and studies can be difficult to navigate for the generalised regulatory scientist.

This ebook clearly lays out what the tests are, what science they are based on, what the regulatory pathway can be and what the limitations to each study and approach are. The video is a great visual aid which brings the OECD guidelines to life for the desk scientist and the table on page 6 makes choosing the right tests for your chemical far easier. This ebook is now a short-cut on my desktop!”

KIRSTY-JO MUDDIMAN, REGULATORY SCIENTIST, MALLARD CONSULTING